Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism

查看全文 作　　者：Yong-Ru [1]Liu;Rui-Xue [1]Tang;Wen-Ting [1]Huang;Fang-Hui [1]Ren;Rong-Quan [2]He;Li-Hua [2]Yang;Dian-Zhong [1]Luo;Yi-Wu [1]Dang;Gang [1]Chen

机构地区：[1]Department of Pathology, First Affiliated Hospital of Guangxi Medical University;[2]Department of Medical Oncology,First Affiliated Hospital of Guangxi Medical University

出　　处：《World Journal of Hepatology》索引2015年第7卷第28期,共11页

基　　金：Supported by Partly Fund of Guangxi Provincial Health Bureau Scientific Research Project,No.Z2014054;Youth Science Foun-dation of Guangxi Medical University,No.GXMUYSF201311;Guangxi University Science and Technology Research Projects,No.LX2014075;Natural Science Foundation of Guangxi;Nos.2015GXNSFBA139157,2015GXNSFCA139009;National Natural Science Foundation of China,Nos.NSFC81360327,NSFC81560489;NSFC81560469 摘　　要：Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncR NAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncR NAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncR NAs in HCC are still deficient, an improved understanding of the roles played by lncR NAs in HCC will lead to a much more effective utilization of those lnc RNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC. 关键词：HEPATOCELLULAR carcinoma LONG noncodingRNA DYSREGULATION MECHANISM Pathway

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Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism

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