Management of non-alcoholic fatty liver disease in 2015

查看全文 作　　者：Neel [1]Malhotra;Melanie D [1,2]Beaton

机构地区：[1]Department of Medicine,Division of Gastroenterology, Western University;[2]London Health Sciences Centre, University Hospital

出　　处：《World Journal of Hepatology》索引2015年第7卷第30期,共6页

摘　　要：There is no single pharmacologic therapy that has been approved to treat nonalcoholic fatty liver disease in the general population. The backbone of therapy currently includes intensive lifestyle modification withestablished targets for diet and weight loss. The use of unsweetened, unfiltered coffee along with limiting high fructose corn syrup have emerged as beneficial dietary recommendations. The use of empiric oral hypoglycemic agents and vitamin E, however, has not been widely accepted. Developing bariatric surgical techniques are promising, but additional studies with long-term follow up are needed before it can be widely recommended. Finally, liver transplantation is an increasingly frequent consideration once complications of endstage disease have developed. The future treatment of those with nonalcoholic fatty liver disease will likely involve a personalized approach. The importance of the gut microbiome in mediating hepatocyte inflammation and intestinal permeability is emerging and may offer avenues for novel treatment. The study of anti-fibrotic agents such as pentoxifylline and FXR agonists hold promise and new pathways, such as hepatocyte cannabinoid receptor antagonists are being studied. With the incidence of obesity and the metabolic syndrome increasing throughout the developed world, the future will continue to focus on finding novel agents and new applications of existing therapies to help prevent and to mediate the progression of nonalcoholic fatty liver disease. 关键词：LOBULAR inflammation Non-alcoholic fattyliver disease Non-alcoholic STEATOHEPATITIS Liver FIBROSIS

相关文献

参考文献（34）
引证文献（6）
耦合文献（11）

参考文献(34)

引证文献(6)

耦合文献(11)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Management of non-alcoholic fatty liver disease in 2015

参考文献(34)

引证文献(6)

耦合文献(11)

用户提示