Dynamic modulation of innate immunity programming and memory

查看全文 作　　者：Ruoxi [1]Yuan;Liwu [1]Li

机构地区：[1]Department of Biological Science, Pathobiology and Biomedical Sciences, Virginia Tech

出　　处：《Science China(Life Sciences)》索引2016年第59卷第1期,共6页

基　　金：the support from the National Institute of Health grant HL 115835 摘　　要：Recent progress harkens back to the old theme of immune memory, except this time in the area of innate immunity, to which traditional paradigm only prescribes a rudimentary first-line defense function with no memory. However, both in vitro and in vivo studies reveal that innate leukocytes may adopt distinct activation states such as priming, tolerance, and exhaustion, depending upon the history of prior challenges. The dynamic programming and potential memory of innate leukocytes may have far-reaching consequences in health and disease. This review aims to provide some salient features of innate programing and memory, patho-physiological consequences, underlying mechanisms, and current pressing issues. 关键词：免疫记忆动态调节免疫规划先天免疫防御功能动态规划病理生理白细胞

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Dynamic modulation of innate immunity programming and memory

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