Successful living donor intestinal transplantation in crossmatch positive recipients: Initial experience

查看全文 作　　者：Raquel Garcia-[1]Roca;Ivo G [1]Tzvetanov;Hoonbae [1]Jeon;Elisabeth [2]Hetterman;Jose [1]Oberholzer;Enrico [1]Benedetti

机构地区：[1]Division of Transplantation, Department of Surgery, University of Illinois at Chicago Hospital and Heals Sciences Systems;[2]Department of Pharmacy practice (MC886), College of Pharmacy, University of Illinois at Chicago Hospital and Heals Sciences Systems

出　　处：《World Journal of Gastrointestinal Surgery》索引2016年第8卷第1期,共5页

摘　　要：Sensitized patients tend to have longer waiting times on the deceased donor list and are at increased risk of graft loss from acute or chronic rejection compared to non-sensitized candidates. Desensitization protocols are utilized to decrease the levels of alloantibodies and to convert an initial positive cross-match to prospective donors into a negative crossmatch. These procedures are mostly available in the setting of living donation. Due to the elective nature of the procedure, desensitization protocols can be extended until the desire result is obtained prior to transplantation. We present two cases of successful desensitization protocol applied to living donor intestinal transplant candidates that converted to negative cross-match to their donors. We present two cases of intestinal transplant candidates with a potential living donor to whom they are sensitized. Both cases underwent successful transplantation after desensitization protocol. No evidence of humoral rejection has occurred in either recipient. Living donor intestinal transplantation in sensitized recipients against the prospective donors provides the ability to implement a desensitization protocol to convert to negative crossmatch. 关键词：Living DONOR POSITIVE CROSSMATCH Intestinal transplant DESENSITIZATION protocol DONOR specificantibody PLASMAPHERESIS

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Successful living donor intestinal transplantation in crossmatch positive recipients: Initial experience

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