Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease

查看全文 作　　者：Pingping [1]Song;Shanshan [1]Li;Hao [2]Wu;Ruize [1]Gao;Guanhua [1]Rao;Dongmei [3]Wang;Ziheng [2]Chen;Biao [1]Ma;Hongxia [1]Wang;Nan [3]Sui;Haiteng [4]Deng;Zhuohua [5]Zhang;Tieshan [2]Tang;Zheng [2]Tan;Zehan [6]Han;Tieyuan [6]Lu;Yushan [1]Zhu;Quan [1,2]Chen 机构地区：[1]State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences,Nankai University, Tianjin 300071, China;[2]State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences,Beijing 100101, China;[3]Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;[4]College of Life Sciences, Tsinghua University, Beijing 100084, China;[5]State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University, Changsha 410078, China;[6]Department of Health and Sports Science, Tianjin University of Sport, Tianjin 300381, China 出　　处：《Protein & Cell》索引2016年第7卷第2期,共16页 基　　金：We are grateful to Drs. Ted Dawson and Jian Feng for generously providing the plasmids. We are also grateful to Professor Mark Bartlam from Nankai University, Tianjin, China for a critical reading of the manuscript. The research was supported by the National Basic Research Program (973 Program) (No. 2011 CB910903) from MOST and project (Grant Nos. 81130045, 31471300, 31271529, 301520103904) from the National Natural Science Foundation of China. 关 键 词：神经元细胞 帕金森病 蛋白酶体 发病机制 易损性 降解 泛素连接酶 酪氨酸羟化酶