Anti-inflammatory properties of lipoxin A4 protect against diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury

查看全文 作　　者：Jiang-quan [1]Han;Cheng-ling [1]Liu;Zheng-yuan [1]Wang;Ling [1]Liu;Ling [1]Cheng;Ya-dan [1]Fan

机构地区：[1]Department of Neurology,Fifth Affiliated Hospital of Zunyi Medical College

出　　处：《Neural Regeneration Research》索引2016年第11卷第4期,共5页

基　　金：supported by a grant from the Zhuhai Key Discipline Project of China,No.200880 摘　　要：Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction,but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury.In this study,we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin.We then induced focal cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours.After administration of lipoxin A4 via the lateral ventricle,infarction volume was reduced,the expression levels of pro-inflammatory factors tumor necrosis factor alpha and nuclear factor-kappa B in the cerebral cortex were decreased,and neurological functioning was improved.These findings suggest that lipoxin A4 has strong neuroprotective effects in diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury and that the underlying mechanism is related to the anti-inflammatory action of lipoxin A4. 关键词：缺血/再灌注损伤大脑皮层糖尿病合并抗炎肿瘤坏死因子-α 核因子-ΚB 缺血再灌注损伤

相关文献

参考文献（36）
引证文献（21）
耦合文献（0）

参考文献(36)

引证文献(21)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Anti-inflammatory properties of lipoxin A4 protect against diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury

参考文献(36)

引证文献(21)

用户提示