Methylprednisolone for acute spinal cord injury: an increasingly philosophical debate

查看全文 作　　者：Christian [1]A.Bowers;Bornali [1]Kundu;Gregory [1]W.J.Hawryluk

机构地区：[1]Department of Neurosurgery, Clinical Neurosciences Center, University of Utah

出　　处：《Neural Regeneration Research》索引2016年第11卷第6期,共4页

摘　　要：Following publication of NASCIS Ⅱ, methylprednisolone sodium succinate(MPSS) was hailed as a breakthrough for patients with acute spinal cord injury(SCI). MPSS use for SCI has since become very controversial and it is our opinion that additional evidence is unlikely to break the stalemate amongst clinicians. Patient opinion has the potential to break this stalemate and we review our recent findings which reported that spinal cord injured patients informed of the risks and benefits of MPSS reported a preference for MPSS administration. We discuss the implications of the current MPSS debate on translational research and seek to address some misconceptions which have evolved. As science has failed to resolve the MPSS debate we argue that the debate is an increasingly philosophical one. We question whether SCI might be viewed as a serious condition like cancer where serious side effects of therapeutics are tolerated even when benefits may be small. We also draw attention to the similarity between the side effects of MPSS and isotretinoin which is prescribed for the cosmetic disorder acne vulgaris. Ultimately we question how patient autonomy should be weighed in the context of current SCI guidelines and MPSS's status as a historical standard of care. 关键词：急性脊髓损伤哲学 MPSS 甲基强的松龙临床医生治疗药物异维A酸 SCI

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Methylprednisolone for acute spinal cord injury: an increasingly philosophical debate

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