Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys

查看全文 作　　者：Jin [1,2]Yang;Yaqi [1,2]An;Haiyan [1,2]Wu;Miao [1,2]Liu;Weiguang [1]Wang;Xue [1]Du;Yan [1]Li;Jianxin [1]Pu;Handong [1]Sun

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;[2]University of Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Science China Chemistry》索引2016年第59卷第9期,共5页

基　　金：supported by the NSFC-Joint Foundation of Yunnan Province (U1302223);the National Natural Science Foundation of China (21322204);the West Light Foundation of the Chinese Academy of Sciences (J-X Pu) 摘　　要：Four new diterpenoids, phyllostachysins I–L(1–4), along with a known one, hebeiabinin B(5), were isolated from the aerial parts of Isodon phyllostachys(I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells. 关键词：二萜 RAW264.7细胞松香烷人乳腺癌细胞 HL-60 细胞毒活性人肝癌细胞 A-549

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Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys

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