Yiguanjian cataplasm attenuates opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome

查看全文 作　　者：Gao [1]Shuai;Gao [2]Hong;Fan [1,3]Yuchen;Zhang [2]Guanghua;Sun [1]Fengkai;Zhao [1]Jing;Li [1]Feng;Yang [1]Yang;Wang [1,3]Kai

机构地区：[1]Department of Hepatology,Qilu Hospital of Shandong Uni-versity,jinan 250012,China;[2]Research Center for Material Evidence Identification,Shandong Public Security Bureau,ji-nan 250012,China;[3]Institute of Hepatology,Shandong University,jinan 250012,China

出　　处：《Journal of Traditional Chinese Medicine》索引2016年第36卷第4期,共7页

基　　金：Supported by Shandong Foundation for Development of Science and Technology,China(Research and Development of Umbilical Treatment Cataplasm for Drug Rehabilitation,No.2009GG10008007) 摘　　要：OBJECTIVE:To investigate the effect of Yiguanjian(YGJ) cataplasm on the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome.METHODS:One hundred Swiss albino mice,of equal male to female ratio,were randomly and equally divided into 10 groups.A portion(3 cm2) of the backside hair of the mice was removed 1 day prior to the experiment.Morphine(5 mg/kg) was intraperitoneally administered twice daily for 5days.YGJ cataplasm was prepared and pasted on the bare region of the mice immediately beforemorphine administration on day 3 and subsequently removed at the end day 5.On day 6,naloxone(8mg/kg) was intraperitoneally injected to precipitate opioid withdrawal syndrome.Behavioral observation was performed in two 30-min phases immediately after naloxone injection.RESULTS:The YGJ cataplasm significantly and dose-dependently attenuated morphine-naloxone-induced experimental opioid withdrawal,in terms of withdrawal severity score and the frequencies of jumping,rearing,forepaw licking,and circling behaviors.However,YGJ cataplasm treatment did not alter the acute analgesic effect of morphine.CONCLUSION:YGJ cataplasm could attenuate opioid dependence and its associated withdrawal symptoms.Therefore,YGJ cataplasm could serve as a potential therapy for opioid addiction in the future. 关键词：Yi Guan Jian PASTE MORPHINE Nalox one Opioid dependence

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Yiguanjian cataplasm attenuates opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome

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