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Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/β-catenin signaling pathway activation

查看全文 作　　者：Gong-biao [1]Lu;Fu-wen [1]Niu;Ying-chun [2]Zhang;Lin [3]DU;Zhi-yuan [1]Liang;Yuan [1]Gao;Ting-zhen [1]Yan;Zhi-kui [1]Nie;Kai [1]Gao 高影响力作者 机构地区：[1]Department of Orthopedics, Jining No.1 People's Hospital, Jining, Shandong Province, China;[2]Department of Interventional Radiology, Jining No. 1 People's Hospital, Jining, Shandong Province, China;[3]Jining Medical University, Jining, Shandong Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2016年第11卷第11期,共8页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China,No.81471854 摘　　要：Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury,and expression levels of specific proteins,including low-density lipoprotein receptor related protein-6 phosphorylation,β-catenin,and glycogen synthase kinase-3β,are significantly altered.We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/β-catenin signaling pathway.In the current study,30 mg/kg methylprednisolone was injected into rats with spinal cord injury immediately post-injury and at 1 and 2 days post-injury.Basso,Beattie,and Bresnahan scores showed that methylprednisolone treatment significantly promoted locomotor functional recovery between 2 and 6 weeks post-injury.The number of surviving motor neurons increased,whereas the lesion size significantly decreased following methylprednisolone treatment at 7 days post-injury.Additionally,caspase-3,caspase-9,and Bax protein expression levels and the number of apoptotic cells were reduced at 3 and 7days post-injury,while Bcl-2 levels at 7 days post-injury were higher in methylprednisolone-treated rats compared with saline-treated rats.At 3 and 7 days post-injury,methylprednisolone up-regulated expression and activation of the Wnt/β-catenin signaling pathway,including low-density lipoprotein receptor related protein-6 phosphorylation,β-catenin,and glycogen synthase kinase-3β phosphorylation.These results indicate that methylprednisolone-induced neuroprotection may correlate with activation of the Wnt/β-catenin signaling pathway. 关 键 词：Β-CATENIN 甲基强的松龙 脊髓损伤 信号通路 WNT 激活 神经功能 Caspase-3
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