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Toll-like Receptor 1 Polymorphisms Increased the Risk of Pulmonary Tuberculosis in an Iranian Population Sample

查看全文 作　　者：Mohammad [1]Naderi;Mohammad [2]Hashemi;Hamideh [1]Mirshekari;Gholamreza [2]Bahari;Mohsen [3]Taheri 高影响力作者 机构地区：[1]Infectious Diseases and Tropical Medicine Research Center,Zahedan University of Medical Sciences;[2]Department of Clinical Biochemistry,School of Medicine,Zahedan University of Medical Sciences;[3]Department of Genetics,School of Medicine,Zahedan University of Medical Sciences高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2016年第29卷第11期,共4页高影响力期刊 基　　金：funded by a dissertation research grant (M.D. thesis of HM #7264) from the Zahedan University of Medical sciences 摘　　要：A case-control study was carried out that involved 203 individuals diagnosed with pulmonary tuberculosis (PTB) and 203 healthy subjects. Genotyping of TLR1 rs5743551 and rs5743618 polymorphisms was done using polymerase chain reaction-restriction fragments length polymorphism assay. We found that TLR1 rs5743551 variant affected the risk of PTB in the codominant (OR=3.28, 95% CI=1.98-5.45, P<0.0001, GA vs. GG; OR=1.86, 95% CI=1.05-3.28, P=0.033, AA vs. GG) and dominant (OR=2.69, 95% CI=1.67-4.34, P<0.0001, GA+AA vs. GG) inheritance models tested. The A allele was associated with a higher risk of PTB than the G allele (OR=1.33, 95% CI=1.01-1.75, P=0.049). The TG genotype of the rs5743618 variant significantly increased the risk of PTB compared to the risk associated with the TT genotype (OR=3.29, 95% CI=1.82-5.97, P<0.0001). The G allele was associated with a higher risk of PTB than the T allele (OR=3.00, 95% CI=1.69-5.31, P=0.0001). Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample. Additional studies with larger sample sizes and involving subjects of different ethnicities are required to validate our present findings. 关 键 词：基因多态性 TOLL样受体 肺结核 样本量 风险 限制性片段长度多态性分析 人口 伊朗
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