Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

查看全文 作　　者：Yan-Ping [1,2]Mao;Ling-Long [1,2]Tang;Lei [1,2]Chen;Ying [1,2]Sun;Zhen-Yu [1,2]Qi;Guan-Qun [1,2]Zhou;Li-Zhi [1,3]Liu;Li [1,3]Li;Ai-Hua [4]Lin;Jun [1,2]Ma

机构地区：[1]State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Sun Yat-sen University Cancer Center;[2]Department of Radiation Oncology,Sun Yat-sen University Cancer Center;[3]Imaging Diagnosis and Interventional Center,Sun Yat-sen University Cancer Center;[4]Department of Medical Statistics and Epidemiology,School of Public Health,Sun Yat-sen University

出　　处：《Chinese Journal of Cancer》索引2016年第35卷第12期,共10页

基　　金：supported by grants from the Key Laboratory Construction Project of Guangzhou City,China (121800085);the Health & Medical Collaborative Innovation Project of Guangzhou City,China (201400000001);the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2014BAI09B10);the National Natural Science Foundation of China (81201746);the Planned Science and Technology Project of Guangdong Province,China (2013B020400004) 摘　　要：Background: The prognostic values of staging parameters require continual re?assessment amid changes in diag?nostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non?meta?static nasopharyngeal carcinoma(NPC) in the intensity?modulated radiotherapy(IMRT) era.Methods: We reviewed the data from 749 patients with newly diagnosed, biopsy?proven, non?metastatic NPC in our cancer center(South China, an NPC endemic area) between January 2003 and December 2007. All patients under?went magnetic resonance imaging(MRI) before receiving IMRT. The actuarial survival rates were estimated using the Kaplan–Meier method, and survival curves were compared using the log?rank test. Multivariate analyses with the Cox proportional hazards model were used to test for the independent prognostic factors by backward eliminating insigniicant explanatory variables.Results: The 5?year occurrence rates of local failure, regional failure, locoregional failure, and distant failure were 5.4, 3.0, 7.4, and 17.4%, respectively. The 5?year survival rates were as follows: local relapse?free survival, 94.6%; nodal relapse?free survival, 97.0%; distant metastasis?free survival, 82.6%; disease?free survival, 75.1%; and overall survival, 82.0%. Multivariate Cox regression analysis revealed that orbit involvement was the only signiicant prognostic fac?tor for local failure(P = 0.011). Parapharyngeal tumor extension, retropharyngeal lymph node involvement, and the laterality, longest diameter, and Ho's location of the cervical lymph nodes were signiicant prognostic factors for both distant failure and disease failure(all P < 0.05). Intracranial extension had signiicant prognostic value for distant failure(P = 0.040).Conclusions: The key failure pattern for NPC was distant metastasis in the IMRT era. With changes in diagnostic and therapeutic technologies as well as treatment modalities, the signiicant prognostic parameters for local control have also been altered substantially. 关键词：Nasopharyngeal carcinoma Intensity-modulated radiotherapy PROGNOSIS Failure pattern Tumor staging

相关文献

参考文献（41）
引证文献（47）
耦合文献（33）

参考文献(41)

引证文献(47)

耦合文献(33)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

参考文献(41)

引证文献(47)

耦合文献(33)

用户提示