Effect of Low Level Subchronic Microwave Radiation on Rat Brain

查看全文 作　　者：Pravin Suryakantrao [1]Deshmukh;Kanu [1]Megha;Namita [1,2]Nasare;Basu Dev [1]Banerjee;Rafat Sultana [1]Ahmed;Mahesh Pandurang [3]Abegaonkar;Ashok Kumar [3]Tripathi;Pramod Kumari [2]Mediratta

机构地区：[1]Environmental Biochemistry and Molecular Biology Laboratory,Department of Biochemistry.University College of Medical Sciences & G.T.B.Hospital(University of Delhi);[2]Department of Pharmacology,University College of Medical Sciences & G.T.B.Hospital(University of Delhi);[3]Centre for Applied Research in Electronics(CARE),Indian Institute of Technology

出　　处：《Biomedical and Environmental Sciences》索引2016年第29卷第12期,共10页

基　　金：Indian Council of Medical Research (ICMR),New Delhi for grant in the form of the extramural research project vide sanction letter No.5/8/4-4(env) 07-NCD-I dated 3-08-09;One of the authors Pravin Suryakantrao Deshmukh is grateful to ICMR for Senior Research Fellowship (SRF) support 摘　　要：Objective The present study was designed to investigate the effects of subchronic low level microwave radiation(MWR) on cognitive function,heat shock protein 70(HSP70) level and DNA damage in brain of Fischer rats.Methods Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies: 900,1800,and 2450 MHz.Animals were divided into 4 groups: Group I: Sham exposed,Group II: animals exposed to microwave radiation at 900 MHz and specific absorption rate(SAR) 5.953 × 10-4 W/kg,Group III: animals exposed to 1800 MHz at SAR 5.835 × 10-4 W/kg and Group IV: animals exposed to 2450 MHz at SAR 6.672 × 10-4 W/kg.All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues.HSP70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay.Results Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function,increase in HSP70 level and DNA damage in brain.Conclusion The results of the present study suggest that low level microwave exposure at frequencies 900,1800,and 2450 MHz may lead to hazardous effects on brain. 关键词：大脑认知功能彗星试金 DNA 损坏 HSP70 微波放射

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Effect of Low Level Subchronic Microwave Radiation on Rat Brain

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