Nat Cell Biol:研究发现人肝细胞抵抗HCV感染的代谢过程

查看全文 作　　者：Gahl Levy, Naomi Habib, Maria Angela Guzzardi, Daniel Kitsberg, David Bomze, Elishai Ezra, Merav Cohen, Nir Friedman ; Yaakov [1]Nahmias;Gahl Levy, Daniel Kitsberg, David Bomze, Merav Cohen, Nir Friedman ; Yaakov [2]Nahmias;Naomi [3]Habib;Maria Angela [4]Guzzardi;Elishai [5]Ezra;Basak E Uygun ; Korkut [6]Uygun;Martin Trippler ; Joerg F [7]Schlaak;Oren [8]Shibolet;Ella H [9]Sklan;Joerg [10]Timm 机构地区：[1]Grass Center for Bioengineering, Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.;[2]Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.;[3]Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.;[4]Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.;[5]Faculty of Engineering, Jerusalem College of Technology, Jerusalem, Israel.;[6]Center for Engineering in Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.;[7]Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany.;[8]Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv, Israel.;[9]Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.;[10]Institute for Virology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany. 出　　处：《现代生物医学进展》索引2016年第16卷第35期,共2页 摘　　要：病毒感染是二十一世纪面临的主要医学挑战之一,从影响全球3%人口的丙肝病毒(HCV)流行病到最近爆发的西尼罗河病毒、寨卡病毒和埃博拉病毒感染。病毒缺乏进行自我复制所需的基础代谢机制。为了解决这个问题,它们劫持它们的宿主的代谢机制以便完成它们的生命周期和进行增殖。然而,科学家们仍然并没有很好地理解病毒与它们感染的有机体之间在代谢上的相互作用。这主要是因为人基因与代谢过程之间存在复杂的相互作用。 关 键 词：病毒感染 代谢过程 Cell 人肝细胞 Nat HCV 西尼罗河病毒 代谢机制