Epidemiological and etiological investigation of dengue fever in the Fujian province of China during 2004–2014

查看全文 作　　者：Jinzhang [1]Wang;Hongbing [1]Chen;Meng [1]Huang;Yongjun [1]Zhang;Jianfeng [1]Xie;Yansheng [1,2]Yan;Kuicheng [1,2]Zheng;Yuwei [1,2]Weng

机构地区：[1]Fujian Center for Disease Control and Prevention, Fuzhou 350001, China;[2]College of public health, Fujian Medicine University, Fuzhou 350001, China

出　　处：《Science China(Life Sciences)》索引2017年第60卷第1期,共9页

基　　金：supported by Chinese National Hi-Tech research development plan (2011AA02A114);Chinese National Major Science & technology project (2012ZA10004-210);Fujian provincial medical innovation project (2015-CXB-13) 摘　　要：Dengue fever(DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004–2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612(83.5%) occurred during the peak period from August to October. Additionally, 76%(190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes(I, IV, V) of DENV1, and one genotype each of DENV2(cosmopolitan) and DENV3(I) circulated in Fujian during 2004–2014. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian. 关键词：流行病学调查福建省病毒分离株病因热调中国系统发育分析登革热

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Epidemiological and etiological investigation of dengue fever in the Fujian province of China during 2004–2014

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