ALK gene expression status in pleural effusion predicts tumor responsiveness to crizotinib in Chinese patients with lung adenocarcinoma

查看全文 作　　者：Zheng [1]Wang;Xiaonan [2]Wu;Xiaohong [3]Han;Gang [2]Cheng;Xinlin [4]Mu;Yuhui [5]Zhang;Di [1]Cui;Chang [6]Liu;Dongge [1]Liu;Yuankai [3]Shi

机构地区：[1]Department of Pathology, Beijing Hospital,National Center of Gerontology;[2]Department of Medical Oncology, Beijing Hospital,National Center of Gerontology;[3]Department of Medical Oncology, National Cancer Center/Cancer Institute &Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College;[4]Department of Respiratory and Critical Care Medicine, Peking University People's Hospital;[5]Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University;[6]Department of Medical Oncology, PLA Army General Hospital

出　　处：《Chinese Journal of Cancer Research》索引2016年第28卷第6期,共11页

基　　金：supported by grants from the Beijing Municipal Science and Technology Commission(D141100000214003);the Natural Science Foundation of China(No.81641114) 摘　　要：Objective: The relationship between anaplastic lymphoma kinase(ALK) expression in malignant pleural effusion(MPE) samples detected only by Ventana immunohistochemistry(IHC) ALK(D5F3) and the efficacy of ALKtyrosine kinase inhibitor therapy is uncertain.Methods: Ventana anti-ALK(D5F3) rabbit monoclonal primary antibody testing was performed on 313 cell blocks of MPE samples from Chinese patients with advanced lung adenocarcinoma, and fluorescence in situ hybridization(FISH) was used to verify the ALK gene status in Ventana IHC ALK(D5F3)-positive samples. The follow-up clinical data on patients who received crizotinib treatment were recorded.Results: Of the 313 MPE samples, 27(8.6%) were confirmed as ALK expression-positive, and the Ventana IHC ALK(D5F3)-positive rate was 17.3%(27/156) in wild-type epidermal growth factor receptor(EGFR) MPE samples. Twenty-three of the 27 IHC ALK(D5F3)-positive samples were positive by FISH. Of the 11 Ventana IHC ALK(D5F3)-positive patients who received crizotinib therapy, 2 patients had complete response(CR), 5 had partial response(PR) and 3 had stable disease(SD).Conclusions: The ALK gene expression status detected by the Ventana IHC ALK(D5F3) platform in MPE samples may predict tumor responsiveness to crizotinib in Chinese patients with advanced lung adenocarcinoma. 关键词：状态预测基因表达 ALK 胸腔积液肺腺癌患者治疗反应

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ALK gene expression status in pleural effusion predicts tumor responsiveness to crizotinib in Chinese patients with lung adenocarcinoma

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