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Hierarchical Micropore/Nanorod Apatite Hybrids In-Situ Grown from 3-D Printed Macroporous Ti6Al4V Implants with Improved Bioactivity and Osseointegration

查看全文 作　　者：Peng [1,2]Xiu;Zhaojun [3]Jia;Jia [1,2]Lv;Chuan [1,2]Yin;Hong [1,2]Cai;Chunli [1,2]Song;Huijie [1,2]Leng;Yufeng [3,4]Zheng;Zhongjun [1,2]Liu;Yan [3]Cheng 高影响力作者 机构地区：[1]Department of Orthopedics,Peking University Third Hospital,Belting 100191,China;[2]Beijing Key Laboratory of Spinal Diseases,Beijing 100191,China;[3]Center for Biomedical Materials and Tissue Engineering,Academy for Advanced Interdisciplinary Studies.Peking University,Beijing 100871,China;[4]Department of Materials Science and Engineering,College of Engineering,Peking University,Beijing 100871,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2017年第33卷第2期,共8页高影响力期刊 基　　金：the Beijing AKEC Medical Co.,Ltd;Medical Research Center of Peking University Third Hospital;supported by the Project of Scientific and Technical Plan of Beijing(Nos.Z121100005312005 and Z141100002814008) 摘　　要：The advent of three-dimensional(3-D) printed technique provides great possibility in the fabrication of customized porous titanium(Ti) implant. However, the bioinert property of the printed Ti poses an outstanding problem. Hybrid micro-arc oxidation and hydrothermal(MAO–HT) treatment on porous metals is able to produce multi-scaled hierarchical orthopedic implant, showing great potential for surface modification of 3-D printed implant. In this study, cylindrical porous Ti6Al4V(Ti64) scaffolds with pore size of 640 μm, porosity of 73% were 3-D printed by electron beam melting process, and their surfaces were left untreated or treated by a combined MAO–HT procedure. In vitro bioactivity was tested by immersion in simulated body fluid for different time points. Then, 12 scaffolds in each group were implanted into the femoral condyles of New Zealand rabbit for 8 weeks. Osseointegration was evaluated by qualitative and quantitative histological analysis, and the bone ingrowth features were probed by sequential fluorescent labeling at 3 and 6 weeks post-surgery. Following the MAO–HT treatment, the porous Ti64 scaffold was endowed with multi-scaled micro/nano-topographies and high amounts of Ca P on its surface.The treated scaffold exhibited drastically enhanced apatite forming ability compared with the untreated one. In vivo test revealed significantly that a higher amount of bone ingrowth and bone implant contact at the treated scaffold. The 2 types of scaffolds had different patterns of bone ingrowth: the treated scaffold exhibited a pattern of contact osteogenesis, by which bone formed directly on the treated implant surface, whereas bone formed distal to the implant surface of the untreated scaffold. MAO–HT treatment can significantly enhance the in vitro apatite-inducing ability and in vivo osseointegration capacity of 3-D porous Ti64 scaffold and may provide as a viable approach for the fabrication of bioactive 3-D printed porous implant for orthopedic applications. 关 键 词：打印的 3-D 多孔的 Ti6Al4V 微弧的氧化 热水的处理 OSSEOINTEGRATION
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