Polymorphism of D-mannitol:Crystal structure and the crystal growth mechanism

查看全文 作　　者：Weiyi [1]Su;Na [1]Jia;Hongshi [1]Li;Hongxun [2]Hao;Chunli [1]Li

机构地区：[1]School of Chemical Engineering and Technology, Hebei University of Technology;[2]School of Chemical Engineering and Technology, Tianjin University

出　　处：《Chinese Journal of Chemical Engineering》索引2017年第25卷第3期,共5页

基　　金：Supported by the National Natural Science Foundation of China(No.21406049);the Natural Science Foundation of Hebei Province(B2015202090);the China Postdoctoral Science Foundation(2015M581283) 摘　　要：The polymorphism of D-Mannitol(mannitol) is reviewed in this paper. It was found that the structure of the stable form is consistent in most literatures, but different authors have given different information about the two metastable forms. Therefore the commonly used nomenclature of mannitol was summarized based on the crystal unit cell parameters with the help of X-ray powder diffraction. Moreover, the crystal growth mechanism of mannitol polymorphs was summarized. Considering the lack of kinetic data for the metastable form especially, a reported method was attempted to apply to δ mannitol in an aqueous cooling crystallization process based on the induction time previously measured, and it was identified that the growth of the δ form follows the two-dimensional(2D) nucleationmediated mechanism. The results also indicate that the method based on induction time and supersaturation should have the potential to be expanded to the metastable polymorphs for the growth property study in a bulk system. 关键词：CRYSTALLIZATION Pharmaceuticals POLYMORPHISM D-MANNITOL Crystal growth

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Polymorphism of D-mannitol:Crystal structure and the crystal growth mechanism

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