Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点

查看全文 作　　者：Genovese, [1]Giannicola;Carugo, [1,2,3]Alessandro;Tepper, [1]James;Robinson, Frederick [1,2]Scott;Li, [1,4]Liren;Svelto, [1,5]Maria;Nezi, [1]Luigi;Corti, [1]Denise;Minelli, [1]Rosalba;Pettazzoni, [1]Piergiorgio;Gutschner, [1]Tony;Wu, Chia-[1]Chin;Seth, [1]Sahil;Akdemir, Kadir [1]Caner;Leo, [2]Elisabetta;Amin, [1,6]Samirkumar;Dal Molin, [7]Marco;Ying, [8]Haoqiang;Kwong, Lawrence [9]N.;Colla, [10]Simona;Takahashi, [1,10]Koichi;Ghosh, [11]Papia;Giuliani, [2]Virginia;Muller, [12]Florian;Dey, [13]Prasenjit;Jiang, [13]Shan;Garvey, [2]Jill;Liu, Chang-[14]Gong;Zhang, [2]Jianhua;Heffernan, Timothy [2,22]P.;Toniatti, [15]Carlo;Fleming, Jason [16]B.;Goggins, Michael [7]G.;Wood, Laura [7]D.;Sgambato, [5]Alessandro;Agaimy, [17]Abbas;Maitra, [18,19]Anirban;Roberts, Charles W. [20,21]M.;Wang, [18]Huamin;Viale, [1]Andrea;DePinho, Ronald [13]A.;Draetta, Giulio [1,2]F.;Chin, [1,2,23]Lynda 机构地区：[1]Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA;[2]Univ Texas MD Anderson Canc Ctr, Inst Appl Canc Sci, Houston, TX 77030 USA;[3]European Inst Oncol, I-20141 Milan, Italy;[4]Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;[5]Univ Cattolica Sacro Cuore, Ist Patol Gen, I-00168 Rome, Italy;[6]Baylor Coll Med, Grad Program Struct & Computat Biol & Mol Biophys, Houston, TX 77030 USA;[7]Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Baltimore, MD 21287 USA;[8]Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA;[9]Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA;[10]Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA;[11]Univ Texas MD Anderson Canc Ctr, Off Technol Commercializat, Houston, TX 77030 USA;[12]Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77030 USA;[13]Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA;[14]Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA;[15]Univ Texas MD Anderson Canc Ctr, ORBIT Platform, Houston, TX 77030 USA;[16]Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA;[17]Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp, Dept Pathol, D-91054 Erlangen, Germany;[18]Friedrich Alexander Univ Erlangen Nuremberg, Dept Pathol, D-91054 Erlangen, Germany;[19]Friedrich Alexander Univ Erlangen Nuremberg, Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R, D-91054 Erlangen, Germany;[20]St Jude Childrens Res Hosp, Ctr Comprehens Canc, Memphis, TN 77027 USA;[21]St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 77027 USA;[22]C4 Therapeut, Cambridge, MA 02142 USA;[23]Univ Texas Syst, Inst Hlth Transformat, Austin, TX 78701 USA 出　　处：《现代生物医学进展》索引2017年第17卷第14期,共2页 摘　　要：在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 关 键 词：胰腺癌 癌细胞 侵袭性 鉴定 异种移植 研究人员 细胞类型 细胞转化