Two-dimensional Pd-based nanomaterials for bioapplications

查看全文 作　　者：Xiaolan [1]Chen;Saige [1]Shi;Jingping [1]wei;Mei [1]Chen;Nanfeng [1]Zheng

机构地区：[1]State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and Engineering Research Center for Nano-Preparation Technology of Fujian Province, College of Chemistry and Chemical Engineering, Xiarnen University, Xiarnen 361005, China

出　　处：《Science Bulletin》索引2017年第62卷第8期,共10页

基　　金：supported by the National Natural Science Foundation of China (21101131, 21420102001);the National Basic Research Program of China (2014CB932004);Natural Science Foundation of Fujian Province (2016J01073) 摘　　要：Noble metal nanomaterials have been extensively explored in cancer diagnostic and therapeutic applications owing to their unique physical and chemical properties, such as facile synthesis, straightforward surface functionalization, strong photothermal effect, and excellent biocompatibility. Herein, we summarize the recent development of two-dimensional(2D) Pd-based nanomaterials and their applications in cancer diagnosis and therapy. Different synthetic strategies for Pd nanosheets and the related nanostructures, including Pd@Au, Pd@Ag nanoplates and mesocrystalline Pd nanocorolla, are first discussed.Together with their unique properties, the potential bioapplications of these 2D Pd nanomaterials are then demonstrated. With strong absorption in near-infrared(NIR) region, these nanomaterials have great potentials in cancer photothermal therapy(PTT). They also readily act as contrast agents in photoacoustic(PA) imaging or X-ray computed tomography(CT) to achieve image-guided cancer therapy. Moreover,significant efforts have been devoted to studying the combination of PTT and other treatment modalities(e.g., chemotherapy or photodynamic therapy) based on Pd nanomaterials. The remarkable synergistic or collaborative effects to achieve better therapeutic efficacy are discussed as well. Additionally, the biosafety of 2D Pd-based nanomaterials in vitro and in vivo was evaluated. Finally, challenges for the applications of Pd-based nanomaterials in cancer diagnosis and therapy, and future research prospects are highlighted. 关键词：金属纳米材料 PD 二维物理化学性质计算机断层扫描肿瘤治疗肿瘤诊断光热效应

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Two-dimensional Pd-based nanomaterials for bioapplications

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