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Effect of electroacupuncture on chemotherapy-induced peripheral neuropathy in patients with malignant tumor:a single-blinded,randomized controlled trial

查看全文 作　　者：Zhang [1]Shiqiang;Wu [1]Tingting;Zhang [1,2]Haisheng;Yang [1]Yun;Jiang [1]Haiyan;Cao [2]Shengcheng;Xie [3]Fang;Xia [1]Xiaoting;Lü [1]Junqiang;Zhong [1]Yi 高影响力作者 机构地区：[1]Department, Shanghai Traditional Chinese Medicine-integratedHospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China;[2]Oncology Department, Fangta Traditional Chinese Medicine Hospital of Songjiang District, Shanghai 201600, China;[3]Oncology Department, Jing'an District CentreHospital of Shanghai, Shanghai 200040, China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2017年第37卷第2期,共6页高影响力期刊 基　　金：Supported by the Study of Electric Acupuncture in Preventing the Peripheral Neuritis Induced by Chemotherapy and Promoting the Immune Function in Cancer Patients from:Comprehensive and Integrative Medicine Institute,Korea;Mechanism Study of Electric Acupuncture in Oxaliplatin-chemotherapy-induced Peripheral Neuropathy by SP-NMDAR Pathway from:Shanghai TCM-integrated Hospital;Effect of Bushen-Jianpi Decoction on Postoperative Recurrence and Vasculogenic Mimicry Formation after Recurrence in Liver Cancer Tissues of Nude Mice with Transplanted Liver Cancer(No.2012J003A);Mechanism Study of Fuzheng Jianpi Decoction on Tumor Metastasis Inhibition by Protecting Intestinal Barrier and Regulating PI3K/AKT Signaling Pathway Expression in Colorectal Tumor Microenvironment(No.15ZR1438700);Effect of Jianpi-Guchang Decoction on the Gut Barrier Function and Immune Function in Lung or Colorectal Cancer Patients Treated by Chemotherapy Based on the Thought of 'Same Treatment for Different Diseases'(No.15401930300);Effect of Jianpi-Guben Decoction on the Gut Barrier Function in Postoperative Colorectal Cancer Patients Treated by Chemotherapy to Balance the Gut Enviroment(No.Hongkou 1502-01) 摘　　要：OBJECTIVE:To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy(CIPN), quality of life and immune status of patients with malignant tumors.METHODS:From Jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of chemotherapy.The chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of treatment.Patients received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of treatment.Then CIPN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of treatment.RESULTS:The gender, age, cancer species as well as incidence(83.3% vs 84.2%) and grades of CIPN before treatments were all similar in patients receiving acupuncture or electroacupuncture(all P >0.05).After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture(84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture(83.3% vs 72.2%).Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment(χ~2= 9.745, P = 0.002).The grades of peripheral neuropathy were significantly different in the two groups post-treatment(χ~2= 13.983, P =0.007).The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively(Z =-4.239, P < 0.001).The electroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture(Z =-4.76, P < 0.001).Both electroacupuncture and acupuncture had no effects on immune function.CONCLUSION:Electroacupuncture could alleviate CIPN, and improve traditional Chinese clinical symptoms and quality of life, but did not affect immune function. 关 键 词：ELECTROACUPUNCTURE 生活的质量 导致化疗的外部神经病 使随机化的控制试用
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