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Evaluation of a granulated formula for the nerve root type and vertebral artery type of cervical spondylosis:a multicenter,single-blind,randomized,controlled,phase Ⅲ clinical trial

查看全文 作　　者：Luo [1]Xiaodong;Wang [2]Peng;Li [1]Zhe;Liang [3]De;Huang [3]Feng;Liu [4]Jinwen;Chen [5]Xinyu;Hu [6]Guoheng;Fang [7]Suting;Zhang [8]Huajian 高影响力作者 机构地区：[1]Department of Encephalopathy, TheSecond Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510370, China;[2]Faculty of Chinese Medicine, Macao Universityof Science and Technology, Macao 999078, China;[3]Department of Orthopaedics, TheFirst Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China;[4]Department of Orthopaedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120, China;[5]Department of Cardiology, The First AffiliatedHospital of Hunan University of Chinese Medicine, Changsha 410007, China;[6]Department of Encephalopathy, The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007, China;[7]Department of Orthopaedics, Hubei Provincial Academy of Chinese Medicine, Wuhan 430074, China;[8]Research Institution, Shineway Pharmaceutical Group Ltd., Shijiazhuang 051430, China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2017年第37卷第2期,共8页高影响力期刊 基　　金：Supported by Shineway Pharmaceutical Group Ltd 摘　　要：OBJECTIVE:To evaluate the effectiveness and safety of cervical spondylosis formula granules in reducing the symptoms of patients with the nerve root type and the vertebral artery type of cervical spondylosis.METHODS:This was a multicenter, single-blind,randomized, controlled trial.From April 2002 to November 2003, 499 patients were randomly assigned to either the treatment or the control group.The treatment group was orally administered granules prepared with a formula for cervical spondylosis, while the control group was given Jingfukang granules.The treatment course was 1 month for both groups.RESULTS:In patients with the nerve root type of cervical spondylosis, the total effect rate in the treatment group(87.21%) was significantly higher than that in the control group(80.70%, P < 0.01).After the treatment period in both groups, the treatment group had a significantly greater rate of resolution of pain, numbness of the upper limbs, muscle strength of the upper limbs, and fatigue than the control group(all P < 0.05).In patients with the vertebral artery type of cervical spondylosis, the total effect rate in the treatment group(82.07%) was similar to that in the control group(71.21%, P >0.05).After the treatment period in both groups,the treatment group had a significantly greater rate of resolution of weakness of the waist and knees than the control group(P < 0.05).CONCLUSION:The cervical spondylosis formula granules significantly improve numbness, muscle strength, and fatigue, and reduce pain in patients with the nerve root type of cervical spondylosis,and improve the weakness of the waist and knees in patients with the vertebral artery type of cervical spondylosis. 关 键 词：SPONDYLOSIS Deficiency of liver and kidney Qi-deficiency blood stasis Jingfukang granules Randomized controlled trial
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