Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility:a meta-analysis

查看全文 作　　者：Xu [1]Hu;Linfei [1]Jiang;Chenhui [1]Tang;Yuehong [1]Ju;Li [2]Jiu;Yongyue [3]Wei;Li [4]Guo;Yang [3]Zhao

机构地区：[1]Department of Biotechnology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China;[2]School of International Pharmaceutical Business,China Pharmaceutical University,Nanjing,Jiangsu 211198,China;[3]Department of Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China;[4]School of Geographic and Biologic Information,Nanjing University of Posts and Telecommunications,Nanjing,Jiangsu 210046,China

出　　处：《The Journal of Biomedical Research》索引2017年第31卷第3期,共13页

基　　金：supported by the National NaturalScience Foundation of China(No.81373102 to YZ,No.61301251 to LG);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.12KJB310003);Priority Academic Program Development of Jiangsu Higher Education Institution(PAPD);Flagship Major Development of Jiangsu Higher Education Institutions;supported by the Qing-lan Project of Jiangsu Province and the Excellent Young Teach Project of Nanjing Medical University 摘　　要：Expression of estrogen receptors is correlated with breast cancer risk,but inconsistent results have been reported.To clarify potential estrogen receptor(ESR)-related breast cancer risk,we analyzed genetic variants of ESR1 in association with breast cancer susceptibility.We performed a meta-analysis to investigate the association between rs2234693,rs1801132,and rs2046210(single nucleotide polymorphisms of ESR1),and breast cancer risk.Our analysis included 44 case-control studies.For rs2234693,the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype.For rs2046210,the AA,GA,or GA + GG genotype had a much higher risk compared to the GG genotype.No significant association was found for the rs 1801132 polymorphism with breast cancer risk.This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk.The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity. 关键词：乳癌雌激素受体 alpha 元分析挑选核苷酸多型性

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Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility:a meta-analysis

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