Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits

查看全文 作　　者：Ding [1]Yu;Yuan [2]Xueling;Wang [2]Yongcheng;Wang [2]Aiyuan;Shi [1]Xian;Wang [1,3]Lu;Daniela [1,3]Litscher;Ingrid [1,3]Gaischek;Irmgard [4]Th.Lippe;Gerhard [1,3]Litscher

机构地区：[1]Department of Acupuncture&Moxibustion,People's Liberation Army General Hospital,Beijing 100853,China;[2]Instituteof Orthopedics,People's Liberation Army General Hospital,Beijing 100853,China;[3]Research Unit for Complementary and Integrative Laser Medicine,Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine,and Traditional Chinese Medicine Research Center Graz,Medical University of Graz,8036 Graz,Austria;[4]Institute of Experimental and Clinical Pharmacology,Medical University of Graz,8036 Graz,Austria

出　　处：《Journal of Traditional Chinese Medicine》索引2017年第37卷第3期,共8页

基　　金：Supported by Beijing medicine research Development Fund:A Clinical Study On ltrasound-guided Acupotomy Treatment of Knee Osteoarthritis(No.SF-2009-46) 摘　　要：OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. 关键词：骨性关节炎透明质酸钠治疗疗法血管内皮生长因子关节软骨玻璃酸钠兔

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Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits

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