Neurotrophic factors and corneal nerve regeneration

查看全文 作　　者：Marta [1]Sacchetti;Alessandro [1]Lambiase

机构地区：[1]Department of Sense Organs, Sapienza University of Rome, Rome, Italy

出　　处：《Neural Regeneration Research》索引2017年第12卷第8期,共5页

摘　　要：The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic support by releasing neuromediators and growth factors. Corneal nerves are easily evaluated for both function and morphology using standard instruments such as corneal esthesiometer and in vivo confocal microscope. All local and systemic conditions that are associated with damage of the trigeminal nerve cause the development of neurotrophic keratitis, a rare degenerative disease. Neurotrophic keratitis is characterized by impairment of corneal sensitivity associated with development of persistent epithelial defects that may progress to corneal ulcer, melting and perforation. Current neurotrophic keratitis treatments aim at supporting corneal healing and preventing progression of corneal damage. Novel compounds able to stimulate corneal nerve recovery are in advanced development stage. Among them, nerve growth factor eye drops showed to be safe and effective in stimulating corneal healing and improving corneal sensitivity in patients with neurotrophic keratitis. Neurotrophic keratitis represents an useful model to evaluate in clinical practice novel neuro-regenerative drugs. 关键词：神经再生神经营养因子和神经生长因子全身性疾病角膜炎评价模型共焦显微镜

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Neurotrophic factors and corneal nerve regeneration

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