维普中文期刊产品整合服务

Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor

查看全文 作　　者：Carolina Castillo [1,2]Hernández;Carlos Felipe [1]Burgos;Angela Hidalgo [2]Gajardo;Tiare Silva-[1]Grecchi;Javiera [1]Gavilan;Jorge Roberto [2]Toledo;Jorge [1]Fuentealba 高影响力作者 机构地区：[1]Laboratory of Screening of Neuroactive Compounds, Department of Physiology, School of Biological Sciences, University of Concepción;[2]Laboratory of Biotechnology and Biopharmaceutical, Department of Pathophysiology, School of Biological Sciences, University of Concepción高影响力机构 出　　处：《Neural Regeneration Research》索引2017年第12卷第9期,共9页高影响力期刊 基　　金：supported by the Innova Proyect,No.13IDL218688;Fondecyt Proyect,No.1130747,1161078;PhD CONICYT Grant,No.21130386 摘　　要：Erythropoietin(Epo) is a fundamental hormone in the regulation of hematopoiesis, and other secondary roles mediated by the binding of the hormone to its specific receptor(Epo R), which leads to an activation of key signaling pathways that induce an increase in cell differentiation, apoptosis control and neuroprotection. It has been suggested that their function depends on final conformation of glycosylations, related with affinity to the receptor and its half-life. The presence of Epo R has been reported in different tissues including central nervous system, where it has been demonstrated to exert a neuroprotective function against oxidative stress conditions, such as ischemic injury and neurodegenerative diseases. There is also evidence of an increase in Epo R expression in brain cell lysates of Alzheimer's patients with respect to healthy patients. These results are related with extensive in vitro experimental data of neuroprotection obtained from cell lines, primary cell cultures and hippocampal slices. Additionally, this data is correlated with in vivo experiments(water maze test) in mouse models of Alzheimer's disease where Epo treatment improved cognitive function. These studies support the idea that receptor activation induces a neuroprotective effect in neurodegenerative disorders including dementias, and especially Alzheimer's disease. Taken together, available evidence suggests that Epo appears to be a central element for Epo R activation and neuroprotective properties in the central nervous system. In this review, we will describe the mechanisms associated with neuroprotection and its relation with the activation of Epo R in order with identify new targets to develop pharmacological strategies. 关 键 词：红细胞生成素受体 神经保护作用 促红细胞生成素 缺血 神经退行性疾病 阿尔茨海默氏症 脑疾病 中枢神经系统
相关文献

参考文献(88)

引证文献(5)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费