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Insights into gastric neuroendocrine tumors burden

查看全文 作  者:Taíssa Maíra Thomaz [1]Araújo;Williams Fernandes [1]Barra;André Salim [1]Khayat;Paulo Pimentel de [1]Assumpcao 高影响力作者 机构地区:[1]Oncology Research Center,Federal University of pará,Para 66073-005,Brazil高影响力机构 出  处:《Chinese Journal of Cancer Research》索引2017年第29卷第2期,共7页高影响力期刊 摘  要:Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. 关 键 词:肿瘤治疗 神经内分泌 攻击性行为 负担 攻击行为 临床治疗 粘膜层
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