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Diagnostic Value of Cerebrospinal Fluid T-SPOT.TB for Tuberculousis Meningitis in China

查看全文 作　　者：LI Xue [1,2,3]Lian;XIE [1,2,3]Na;WANG Song [4]Wang;WU Qian [5]Hong;MA [1,2,3]Yan;SHU [1,2,3]Wei;CHEN Hong [1,2,3]Mei;ZHANG Li [1,2,3]Qun;WU Xiao [1,2,3]Guang;MA Li [1,2,3]Ping;CHE Nan [1,2,3]Ying;GAO Meng [1,2,3]Qiu 高影响力作者 机构地区：[1]Beijing Chest Hospital,Capital Medical University,Beijing 101149,China;[2]Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China;[3]Administration Office,Clinical Center on Tuberculosis Control,Chinese Center for Disease Control and Prevention,Beijing 101149,China;[4]Public Health Monitor and Information Service Center,Chinese Center for Disease Control and Prevention,Beijing 102206,China;[5]Department of Tuberculosis,Prevention and Treatment HosDital of Shanxi Province.Xian 7101130.Shanxi China高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2017年第30卷第9期,共4页高影响力期刊 摘　　要：The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid(CSF) T‐SPOT.TB test for the diagnosis of TB meningitis(TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T‐SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV). A receiver operating characteristic(ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T‐SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients(54.2%) of the 96 enrolled patients. The area under the curve(AUC) was 0.910, and the sensitivities of CSF T‐SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T‐SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM. 关 键 词：诊断价值 脑脊液 脑膜炎 结核 中国 特征曲线 诊断准确性 TBM
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