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Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis

查看全文 作　　者：Xin [1,2]Xu;Xiaoyue [1,2]Jia;Longyi [1]Mo;Chengcheng [1,3]Liu;Liwei [1,4]Zheng;Quan [1,5]Yuan;Xuedong [1,2]Zhou 高影响力作者 机构地区：[1]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University;[2]Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University;[3]Department of Periodontics, West China Hospital of Stomatology, Sichuan University;[4]Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University;[5]Department of Dental Implantology, West China Hospital of Stomatology, Sichuan University高影响力机构 出　　处：《Bone Research》索引2017年第5卷第3期,共18页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(grant numbers 81430011,81470711,and 81670978);the Brilliant Young Investigator Award,Sichuan University(grant number 2015SCU04A16) 摘　　要：Postmenopausal osteoporosis(PMO) is a prevalent metabolic bone disease characterized by bone loss and structural destruction, which increases the risk of fracture in postmenopausal women. Owing to the high morbidity and serious complications of PMO, many efforts have been devoted to its prophylaxis and treatment. The intestinal microbiota is the complex community of microorganisms colonizing the gastrointestinal tract. Probiotics, which are dietary or medical supplements consisting of beneficial intestinal bacteria, work in concert with endogenous intestinal microorganisms to maintain host health. Recent studies have revealed that bone loss in PMO is closely related to host immunity, which is influenced by the intestinal microbiota. The curative effects of probiotics on metabolic bone diseases have also been demonstrated. The effects of the intestinal microbiota on bone metabolism suggest a promising target for PMO management.This review seeks to summarize the critical effects of the intestinal microbiota and probiotics on PMO, with a focus on the molecular mechanisms underlying the pathogenic relationship between bacteria and host, and to define the possible treatment options. 关 键 词：骨质疏松症 肠道菌群 绝经后 治疗 靶点 宿主免疫 肠道细菌 微生物群落
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