维普中文期刊产品整合服务

A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels

查看全文 作　　者：Yesim [1]Coskun;Ceyhun [2]Dalkan;Ozge [3]Yabas;Ozlem Onay [4]Demirel;Elif Samiye [5]Bayar;Sibel [5]Sakarya;Tuba [6]Muftuoglu;Dilaver [7]Ersanli;Nerin [8]Bahceciler;ipek [1,2]Akman 高影响力作者 机构地区：[1]Department of Pedialrics, Bahcesehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey;[2]Department of Pediatrics, Division of Neonatology, Near East University, Nicosia 99138, North Cyprus;[3]Department of Ophtalmotology, Bahce~ehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey;[4]Department of Biochemistry, Bahcesehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey;[5]Department of Public Health, Marmara University Medical Faculty, Istanbu 134890, Turkey;[6]Department of Biochemistry, GATA Haydarpa~a Hospital, Istanbul 34668, Turkey;[7]Department of Ophtalmotology, GATA Haydarpasa Hospital, Istanbu134668, Turkey;[8]Department of Pediatrics, Near East University, Nicosia 99138, North Cyprus高影响力机构 出　　处：《International Journal of Ophthalmology(English edition)》索引2017年第10卷第11期,共6页高影响力期刊 摘　　要：AIM: To detect the impact of insulin-like growth factor-1(IGF-1) and other risk factors for the early prediction of retinopathy of prematurity(ROP) and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS: The study was conducted with 127 preterm infants. IGF-1 levels in the 1 st day of life, 1 st, 2 nd, 3 rd and 4 th week of life was analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrences of any stage ROP. A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS: Birth weights(BW), gestational weeks(GW) and the prevalence of breast milk consumption were lower, respiratory distress syndrome(RDS), bronchopulmonarydysplasia(BPD) and necrotizing enterocolitis(NEC) were more frequent, the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP(P<0.05). Initial serum IGF-1 levels tended to be lower in newborns who developed ROP. Logistic regression analysis revealed that low BW(<1250 g), presence of intraventricular hemorrhage(IVH) and formula feeding increased the risk of ROP. Afterwards, the scoring system was validated on 107 infants. The negative predictive values of a score less than 4 were 84.3%, 74.7% and 79.8% while positive predictive values were 76.3%, 65.5% and 71.6% respectively.CONCLUSION: In addition to BW <1250 g and IVH, formula consumption was detected as a risk factor for the development of ROP. Breastfeeding is important for prevention of ROP in preterm infants. 关 键 词：早熟的 retinopaty 像胰岛素的生长 factor-1 母奶 protectivity
相关文献

参考文献(31)

引证文献(4)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费