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Heyan Kuntai capsule versus dehydroepiandrosterone in treating Chinese patients with infertility caused by diminished ovarian reserve: a multicenter, randomized controlled trial

查看全文 作　　者：Gao [1]Hui;Xia [2]Tian;Ma [2]Ruihong;Zhao [2]Zhimei;Song [3]Xueru;Wang [2]Baojuan;Liu [4]Lijing;Han [4]Kaimei;Wang [4]Guoqing;Fu [5]Yu;Hao [6]Guimin 高影响力作者 机构地区：[1]Department of Traditional Chinese Medicine, Affiliated Hospital of Chengde Medical College, Chengde 067000, China;[2]Department of Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;[3]Department of Reproductive center, Tianjin Medical University General Hospital, Tianjin 300052, China;[4]Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;[5]Department of Acupuncture, First TeachingHospital of Tianjin University of TCM, Tianjin 300193, China;[6]Department of Reproductive Center, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2017年第37卷第4期,共8页高影响力期刊 基　　金：Supported by The Scientific research project of Administration of Traditional Chinese Medicine of Hebei Province:The Clinical Study of Kuntai Capsule in the Treatment of Infertility Women with Diminished Ovarian Reserve Diagnosed Liver-kidney Yin Deficiency and Heart-kidney Imbalance Syndrome(No.2016068) 摘　　要：OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month period.RESULTS: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were observed.CONCLUSION: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment.HYKT might be an alternative to the treatment of infertility caused by DOR. 关 键 词：不孕,女性 卵巢的保守 荷尔蒙 DEHYDROEPIANDROSTERONE Heyan Kuntai 囊 使随机化的控制试用
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