Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots

查看全文 作　　者：Yangyang [1]He;Zhanxian [1]Li;Qingyan [2]Jia;Bingjie [1]Shi;Hongyan [2]Zhang;Liuhe [1]Wei;Mingming [1]Yu

机构地区：[1]College of Chemistry and Molecular Engineering, Zhengzhou University;[2]Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》索引2017年第28卷第10期,共6页

基　　金：supports from National Natural Science Foundation of China (Nos. 21601158, U1504203 and J1210060);Key Laboratory of Photochemical Conversion and Optoelectronic Materials and Zhengzhou University 摘　　要：It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic interaction between carbon nanodots(CDs) and organic molecules, two novel ratiometric fluorescence hybrid nanosensors were fabricated for sensing acidic p H. These nanohybrid systems possess dual emission peaks at 455 and 527 nm under a single excitation wavelength of 380 nm in acidic p H condition.With the increasing of p H, the fluorescence of the 1,8-naphthalimide derivative completely quenches,while the blue fluorescence of CDs keeps constant. Furthermore, the CDsàorganic molecular nanohybrids exhibit excellent anti-disturbance ability, reversible p H sensing ability, and a linear response range in wide p H range respectively. Besides the ability to target lysosome, with one of the nanosensor, stimulated p H change has been successfully tracked in a ratiometric manner via fluorescence imaging. 关键词：Acidic pH Fluorescence Carbon dot Hybrid nanosensor Lysosome-targeted

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Ratiometric fluorescent detection of acidic pH in lysosome with carbon nanodots

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