维普中文期刊产品整合服务

The oxidative DNA damage response: A review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburgh

查看全文 作　　者：[1,2]S.Levine;Luxi [1,2,3]Sun;Rong [1,2,4]Tan;Ying [1,2,3]Gao;Lu [1,2,3]Yang;Hao [1,2,3]Chen;Yaqun [1,2,3]Teng;Li [1,2]Lan 高影响力作者 机构地区：[1]UPMC Hillman Cancer Center Pittsburgh, PA 15213, USA;[2]Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA;[3]School of Medicine, Tsinghua University, Beijing 100084, China;[4]Xiangya Hospital, Central South University, Changsha 410008, China高影响力机构 出　　处：《Science China(Life Sciences)》索引2017年第60卷第10期,共4页高影响力期刊 基　　金：supported in part by grants from the National Institutes of Health GM118833 to LL;project used the UPMC Hillman Cancer Center Cytometry Facility, supported in part by National Institutes of Health P30CA047904 摘　　要：Endogenous stress and exogenous toxicants(chemicals and UV light) alter genetic information either directly or indirectly through the production of reactive oxygen species(ROS), thereby driving genomic instability in cells and promoting tumorigenesis. All living cells try to faithfully preserve and transmit their genomic information from one generation to the next using DNA repair mechanisms to repair oxidative DNA damage to prevent cancer or premature aging. Oxidative DNA damage comprises a mixture of DNA lesions including base damage, DNA single strand breaks(SSBs), and DNA double strand breaks(DSBs). This review summarizes some of the studies on DNA damage response at a defined genome locus that are performed by students from the Tsinghua University School of Medicine and the School of Medicine of Central South University(Xiangya Hospital) at the University of Pittsburgh School of Medicine. A summary of their work highlights the continuous contribution of the students to a particular research program and exemplifies the achievements of this China-U.S. collaborative training program. 关 键 词：DNA damage CHROMATIN TELOMERE DNA repair
相关文献

参考文献(8)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费