Tackling dipeptidyl peptidase Ⅳ in neurological disorders

查看全文 作　　者：Ghaith Al-[1]Badri;Gian Marco [2]Leggio;Giuseppe [3]Musumeci;Rubina [3]Marzagalli;Filippo [2]Drago;Alessandro [1,4]Castorina

机构地区：[1]School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia;[2]Section of Pharmacology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy;[3]Section of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy;[4]Discipline of Anatomy and Histology, School of Medical Sciences, The University of Sydney, Sydney, Australia

出　　处：《Neural Regeneration Research》索引2018年第13卷第1期,共9页

摘　　要：Dipeptidyl peptidase Ⅳ(DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1(GLP-1), pituitary adenylate cyclase-activating polypeptide(PACAP) and glucose-dependent insulinotropic peptide(GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV. 关键词：NEURODEGENERATION INFLAMMATION immune system INSULIN DIABETES ALKALOIDS BERBERINE

相关文献

参考文献（113）
引证文献（1）
耦合文献（6）

参考文献(113)

引证文献(1)

耦合文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Tackling dipeptidyl peptidase Ⅳ in neurological disorders

参考文献(113)

引证文献(1)

耦合文献(6)

用户提示