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Reliability of online near-infrared spectroscopy analysis of the ex-traction process of Huatan Qushi decoction for phlegm-dampness constitution

查看全文 作　　者：Zhao [1]Shipeng;Zheng [1]Yanfei;Li [1]Pin;Liang [1]Xue;Bao [1]Lei;Chen [1]Yu;Yu [1]Ruoxi;Sun [1]Ranran;Li [1]Lingru;Wang [1]Qi 高影响力作者 机构地区：[1]College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2017年第37卷第6期,共6页高影响力期刊 基　　金：Supported by the Chinese National Natural Science Foundation(Study on Differences between the Deficiency-Constitution and Access-Constitution Obesity based on Inhibition at Initiation and Degradation Step of Macrophages Autophagy and Its Epigenetic Regulation Mechanisms,No.81030064);the Beijing Natural Science Foundation(Mechanism of Phlegm-dampness Constitution Turning to Mebabolic Disorders and Effect on Recipe for Reducing Phlegm and Expelling Dampness Based on Technigue of MIcro RNA Chip,No.7162118) 摘　　要：OBJECTIVE: To establish a quantitative model for the online analysis of hesperidin content in the extraction process of Huatan Qushi decoction for individuals with phlegm-dampness constitution by using near-infrared(NIR) spectroscopy and partial least squares(PLS) methods.METHODS: The reference content of hesperidin, an effective ingredient of Huatan Qushi decoction,was determined using high-performance liquid chromatography(HPLC). The modeling band was selected using synergy interval PLS(Si PLS) algorithms, and a PLS model demonstrating the relationship between NIR predictive values and HPLC reference values was established. The optimal modeling route was selected through global optimization of process trace parameters.RESULTS: The root mean square error of cross-validation was 9.8410. The coefficients of determination of the calibration set and prediction set were0.9860(R2 cal) and 0.9458(R_(cal)~2), respectively. The residual predictive deviation was 3.0115. The parameters demonstrated high predictive capability and reliability. The band was selected via the Si PLS method. There were seven latent variables.CONCLUSION: This study provides a favorable comprehensive evaluation method for variable selection and quality control of the Traditional Chinese Medicine extraction process. 关 键 词：Spectroscopy, NEAR-INFRARED LEAST-SQUARES analysis HESPERIDIN PHLEGM DAMPNESS Huatan Qushi DECOCTION
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