Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6

查看全文 作　　者：Kejia [1]Zhao;Leimin [2]Yu;Xi [3]Wang;Yibo [4]He;Bin [5]Lu

机构地区：[1]Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaThe First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China;[2]Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaThe First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China;[3]Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China;[4]Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China;[5]Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China Correspondence address. Tel: +86-571-87032028; E-mail: lvbin@medmail.com.cn

出　　处：《Acta Biochimica et Biophysica Sinica》索引2018年第50卷第2期,共8页

摘　　要：应力导致的内脏的超敏性在急躁的肠症候群(IBS ) 是相当普通的病人。Probiotics 玩在在 IBS 病人减少内脏的超敏性的一个重要角色。然而,机制清楚地没被阐明。在这研究,我们调查了像点头的受体 pyrin 的角色包含域的蛋白质(NLRP6 ) 6 由应力在 Clostridium 调整 butyricum 的 IBS 导致了。我们的结果证明 NLRP6 在 IBS 组冒号纸巾是下面调整的。另外, IL-18, IL-1, myeloperoxidase (军邮局) , d 乳的酸(D-LA ) ,和 CD172a 在 IBS 组是起来调整的结肠有粘液。在 NLRP6 基因是 silenced 以后, IL-18 和 IL-1 也被增加。病理学的分数建议了低发炎结肠有粘液而非终端回肠。水回避应力() 显示出内脏的超敏性到结肠的扩张。然而,有 Clostridium butyricum 的治疗颠倒了这些结果,施加有益的效果。在结论, Clostridium butyricum 可以由禁止低等级发炎在 IBS 的内脏的超敏性上施加一个有益的行动结肠通过它 NLRP6 上的行动有粘液。 关键词：症候群结肠内脏调整粘液 IL-18 IBS 应力

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Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6

参考文献(30)

引证文献(11)

耦合文献(115)

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