Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

查看全文 作　　者：Yuan [1,2]Yue;Sarrabeth [1,2]Stone;Wensheng [1,2]Lin

机构地区：[1]Department of Neuroscience,University of Minnesota;[2]Institute for Translational Neuroscience,University of Minnesota

出　　处：《Neural Regeneration Research》索引2018年第13卷第9期,共9页

基　　金：supported by grants from the National Institutes of Health(NS094151 and NS105689);the National Multiple Sclerosis Society(RG5239-A-3)(to WL) 摘　　要：The transcription factor nuclear factor κB(NF-κB) plays major roles in inflammatory diseases through regulation of inflammation and cell viability.Multiple sclerosis(MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system(CNS).It has been shown that NF-κB is activated in multiple cell types in the CNS of MS patients,including T cells,microglia/macrophages,astrocytes,oligodendrocytes,and neurons.Interestingly,data from animal model studies,particularly studies of experimental autoimmune encephalomyelitis,have suggested that NF-κB activation in these individual cell types has distinct effects on the development of MS.In this review,we will cover the current literature on NF-κB and the evidence for its role in the development of MS and its animal model experimental autoimmune encephalomyelitis. 关键词：脑脊髓炎原子硬化多重试验性免疫自体神经系统

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Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

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引证文献(13)

耦合文献(72)

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