Advances in tumor-endothelial cells co-culture and interaction on microfluidics

查看全文 作　　者：Weiwei [1]Li;Mashooq [1]Khan;Sifeng [1]Mao;Shuo [1]Feng;Jin-Ming [1]Lin

机构地区：[1]Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry& Chemical Biology, Tsinghua University

出　　处：《Journal of Pharmaceutical Analysis》索引2018年第8卷第4期,共9页

基　　金：financial support from National Natural Science Foundation of China (Nos. 214350002, 21727814 and 21621003) 摘　　要：The metastasis in which the cancer cells degrade the extracellular matrix(ECM) and invade to the surrounding and far tissues of the body is the leading cause of mortality in cancer patients. With a lot of advancement in the field, yet the biological cause of metastasis are poorly understood. The microfluidic system provides advanced technology to reconstruct a variety of in vivo-like environment for studying the interactions between tumor cells(TCs) and endothelial cells(ECs). This review gives a brief account of both two-dimensional models and three-dimensional microfluidic systems for the analysis of TCs-ECs coculture as well as their applications to anti-cancer drug screening. Furthermore, the advanced methods for analyzing cell-to-cell interactions at single-cell level were also discussed. 关键词：相互作用房间文化合作癌症病人 VIVO ECM 细胞外

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Advances in tumor-endothelial cells co-culture and interaction on microfluidics

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