Organocatalytic cascade 1,6-conjugate addition/annulation/tautomerization of functionalized para-quinone methides: Access to chiral 2-amino-4-aryl-4H-chromenes

查看全文 作　　者：Cong [1]Duan;Ling [2]Ye;Wenqin [1]Xu;Xinying [1]Li;Feng [1]Chen;Zhigang [1]Zhao;Xuefeng [1]Li 机构地区：[1]College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, China;[2]Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu 610031, China 出　　处：《Chinese Chemical Letters》索引2018年第29卷第8期,共4页 基　　金：financially supported by the National Natural Science Foundation of China(No.21402163);the Fundamental Research Funds for the Central Universities of Southwest Minzu University (No. 2016NGJPY02);the Graduate Innovation Project of Southwest Minzu University (No. CX2017SZ016);the Undergraduate Innovation Project of Southwest Minzu University (No. S201610656092) 摘　　要：A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields(88%-99%) and excellent enantiopurities(86%-99% ee). The functionalized para-Quinone methides(p-OMs) could be facilely obtained. 关 键 词：串联 存取 地被