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Association of serum lipids and severity of epithelial ovarian cancer:an observational cohort study of 349 Chinese patients

查看全文 作　　者：Yi [1]Zhang;Jing [2]Wu;Junya [3]Liang;Xing [1]Huang;Lei [1]Xia;Dawei [1]Ma;Xinyu [1]Xu;Pingping [4]Wu 高影响力作者 机构地区：[1]Department of Pathology, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China;[2]Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China;[3]The School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;[4]Department of Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China.高影响力机构 出　　处：《The Journal of Biomedical Research》索引2018年第32卷第5期,共7页高影响力期刊 基　　金：supported by Jiangsu Cancer Hospital (ZK201606;ZK201610) 摘　　要：While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index(BMI), lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics(FIGO) grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride(TG), and high density lipoproteins(HDL) differed significantly among different stages of epithelial ovarian cancer(P<0.05). In the logistic regression model, elevated TG(OR: 1.883; 95% CI= 1.207-2.937), and low HDL(OR: 0.497; 95% CI = 0.298-0.829) levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development. 关 键 词：TRIGLYCERIDES epithelial ovarian cancer high density lipoproteins DYSLIPIDEMIA clinical data statistics
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