Vascular calcification in chronic kidney disease: Pathogenesis and clinical implication

查看全文 作　　者：Sinee [1]Disthabanchong

机构地区：[1]Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

出　　处：《World Journal of Nephrology》索引2012年第1卷第2期,共11页

基　　金：Supported by The Kidney Foundation of Thailand 摘　　要：Cardiovascular disease is the leading cause of death among patients with chronic kidney disease(CKD). Vascular calcification(VC) is one of the independent risk factors associated with cardiovascular disease and cardiovascular mortality in both the general population and CKD patients. Earlier evidence revealed substantially higher prevalence of VC in young adults on chronic hemodialysis compared to the general population in the same age range, indicating the influence of CKDrelated risk factors on the development of VC. Pathogenesis of VC involves an active, highly organized cellular transformation of vascular smooth muscle cells to bone forming cells evidenced by the presence of bone matrix proteins in the calcified arterial wall. VC occurs in both the intima and the media of arterial wall with medial calcification being more prevalent in CKD. In addition to traditional cardiovascular risks, risk factors specific to CKD such as phosphate retention, excess of calcium, history of dialysis, active vitamin D therapy in high doses and deficiency of calcification inhibitors play important roles in promoting the development of VC. Non-contrast multi-slice computed tomography has often been used to detect coronary artery calcifi-cation. Simple plain radiographs of the lateral lumbar spine and pelvis can also detect VC in the abdominal aorta and femoral and iliac arteries. Currently, there is no specific therapy to reverse VC. Reduction of calcium load, lowering phosphate retention using non-calcium containing phosphate binders, and moderate doses of active vitamin D may attenuate progression. Parenteral sodium thiosulfate has also been shown to delay VC progression. 关键词：慢性肾病患者治疗方法临床分析

相关文献

参考文献（149）
引证文献（23）
耦合文献（0）

参考文献(149)

引证文献(23)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Vascular calcification in chronic kidney disease: Pathogenesis and clinical implication

参考文献(149)

引证文献(23)

用户提示