Vitamin E and diabetic nephropathy in mice model and humans

查看全文 作　　者：Nakhoul [1]Farid;Dahan [1]Inbal;Nakhoul [2]Nakhoul;Farber [1]Evgeny;Rachel Miller-[3]Lotan;Andrew P [3]Levy;Asleh [3]Rabea

机构地区：[1]Department of Nephrology and Hypertension, Baruch-Padeh Poriya Medical Center, Faculty of Medicine, Bar-Ilan University;[2]Ophtalmology Unit, Baruch-Padeh Poriya Medical Center, Lower Galilee 15208, Israel;[3]The Vascular Biology Lab, the Technion Faculty of Medicine, Haifa 31096, Israel

出　　处：《World Journal of Nephrology》索引2013年第2卷第4期,共14页

摘　　要：Diabetes mellitus(DM) is associated with increased oxidative stress due to elevated glucose levels in the plasma. Glucose promotes glycosylation of both plasma and cellular proteins with increased risk for vascular events. Diabetic patients suffer from a higher incidence of cardiovascular complications such as diabetic nephropathy. Haptoglobin(Hp) is an antioxidant plasma protein which binds free hemoglobin, thus preventing heme-iron mediated oxidation. Two alleles exist at the Hp gene locus(1 and 2) encoding three possible Hp genotypes that differ in their antioxidant ability, and may respond differently to vitamin E treatment. Several clinical studies to have shown that Hp 1-1 genotype is a superior antioxidant to the Hp 2-2 genotype and Hp 2-2 genotype is associated with a higher incidence ofcardiovascular disease. Vitamin E was found to have beneficial effect in patient and mice with Hp 2-2 genotype. In this review we have summarized the results of our studies in patients with diabetic nephropathy treated with vitamin E and in diabetic mice with different haptoglobin genotypes. 关键词：糖尿病葡萄糖临床分析治疗方法

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Vitamin E and diabetic nephropathy in mice model and humans

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