Receptor activator of nuclear factorκB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease

查看全文 作　　者：Michalis [1]Spartalis;Aikaterini [1]Papagianni

机构地区：[1]Department of Nephrology,Aristotle University of Thessaloniki,'Hippokration'General Hospital,54642 Thessaloniki,Greece

出　　处：《World Journal of Nephrology》索引2016年第5卷第1期,共5页

摘　　要：Vascular calcifications are commonly observed in patients with chronic kidney disease(CKD) and contribute to the excessive cardiovascular morbidity and mortality rates observed in these patients populations. Although the pathogenetic mechanisms are not yet fully elucidated, recent evidence suggests a link between bone metabolism and the development and progression of vascular calcifications. Moreover, accumulating data indicate that receptor activator of nuclear factor κB ligand/osteoprotegerin axis which plays essential roles in the regulation of bone metabolism is also involved in extra-osseous bone formation. Further studies are required to establish the prognostic significance of the above biomarkers as predictors of the presence and severity of vascular calcifications in CKD patients and of cardiovascular morbidity and mortality. Moreover, randomized clinical trials are needed to clarify whether inhibition of osteoclast activity will protect from vascular calcifications. 关键词：慢性肾脏病血管钙化治疗方法临床分析

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Receptor activator of nuclear factorκB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease

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