Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus

查看全文 作　　者：Francesca [1]Antonelli;Arianna [1]Casciati;Simonetta [1]Pazzaglia

机构地区：[1]Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile(ENEA)

出　　处：《Neural Regeneration Research》索引2019年第14卷第1期,共3页

基　　金：partially supported by grant 15234 from the Associazione Italiana per la Ricerca sul Cancro(AIRC) 摘　　要：The morphogen Sonic Hedgehog(Shh)plays a critical role in the development of different tissues,both in invertebrates and vertebrates.Shh mediates its action via a receptor complex associating two transmembrane proteins:Patched1(Ptch1)and Smoothened(Smo).The repression exerted by Ptch1 on Smo is relieved when Shh,the ligand,binds to Ptch1,which leads to a complex signaling cascade involving the transcription factors of the Gli family and finally,to 关键词：神经发生信号刺猬声音无脊椎动物回转牙齿控制

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Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus

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