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Moisture sorption and diffusion determination of Chinese herbal granules:Moisture-resistant effects of fluidized bed granulation with dextrin

查看全文 作　　者：Peng-jun [1,2,3]Han;Zhi-feng [1,2,3]Xue;Li-na [1,2,3]Zhang;Bing [1,2,3]Zhang;Dong-li [1,2,3]Qi;Jia-xin [1,2,3]Pi;Nan [1,2,3]Li;Pan [1,2,3]Guo;Zhi-dong [1,2,3]Liu 高影响力作者 机构地区：[1]State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine;[2]Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin University of Traditional Chinese Medicine;[3]Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine高影响力机构 出　　处：《Chinese Herbal Medicines》索引2018年第10卷第3期,共8页高影响力期刊 基　　金：financial support provided for this research by Tianjin Municipal Education Commission Research Project(Grant No.2017KJ134) 摘　　要：Objective: To investigate the effects of fluidized bed granulation with dextrin on moisture sorption and diffusion of Zexie Decoction granules.Methods: The particle characterization was studied by the particle size, scanning electron microscopy(SEM), differential scanning calorimetry(DSC), and Fourier transform infrared(FTIR). The moisture sorption isotherm, equilibrium moisture content(EMC), and moisture diffusion coefficients were determined by using the saturated salt solution method.Results: The particle size increased from 6.04 μm(powder) to 1201.47 μm(granule). The glass transition temperature of dextrin, Zexie Decoction powder, and granule was 107.13 °C, 94.82 °C, and 126.25 °C. As the increase of temperature, the initial rate of moisture sorption become higher. Furthermore, the initial rate of moisture sorption of Zexie Decoction granules was lower than those of powders and dextrin. The EMC and moisture diffusion coefficients were reduced significantly after granulation(P < 0.01). Critical relative humidity and diffusion activation energy of granules were higher than powders.Conclusion: Results suggested that fluidized bed granulation with dextrin could reduce the hygroscopicity of the Zexie Decoction extract powders and inhibited moisture diffusion, which is mainly related to the microstructure reorganization by fluidized bed granulation and anti-plasticizing effects of dextrin. 关 键 词：diffusion coefficient fluidized bed moisture-resistant EFFECTS Zexie DECOCTION GRANULES
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