Glutathione depleting drugs, antioxidants and intestinal calcium absorption

查看全文 作　　者：Luciana [1]Moine;María [1]Rivoira;Gabriela Díaz de [1]Barboza;Adriana [1]Pérez;Nori Tolosa de [1]Talamoni

机构地区：[1]Laboratorio 'Dr. Fernando Canas', Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba 5000, Argentina

出　　处：《World Journal of Gastroenterology》索引2018年第24卷第44期,共10页

摘　　要：Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. 关键词：抗氧化剂谷胱甘肽钙吸收 apoptosis Ca2+ 肠氧化还原作用 GSH

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Glutathione depleting drugs, antioxidants and intestinal calcium absorption

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