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Single-cell analysis of tumors:Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells

查看全文 作　　者：Ramin [1]Radpour;Farzad [2]Forouharkhou 高影响力作者 机构地区：[1]Tumor Immunology, Department for Bio-Medical Research (DBMR), University of Bern, Bern 3008, Switzerland;[2]Department of Medical Oncology, Inselspi-tal, Bern University Hospital, University of Bern, Bern 3008, Switzerland高影响力机构 出　　处：《World Journal of Stem Cells》索引2018年第10卷第11期,共12页高影响力期刊 摘　　要：Biomarker-driven individualized treatment in oncology has made tremendous progress through technological developments, new therapeutic modalities and a deeper understanding of the molecular biology for tumors, cancer stem cells and tumor-infiltrating immune cells. Recent technical developments have led to the establishment of a variety of cancer-related diagnostic, prognostic and predictive biomarkers. In this regard, different modern OMICs approaches were assessed in order to categorize and classify prognostically different forms of neoplasia. Despite those technical advancements, the extent of molecular heterogeneity at the individual cell level in human tumors remains largely uncharacterized. Each tumor consists of a mixture of heterogeneous cell types. Therefore, it is important to quantify the dynamic cellular variations in order to predict clinical parameters, such as a response to treatment and or potential for disease recurrence. Recently, single-cell based methods have been developed to characterize the heterogeneity in seemingly homogenous cancer cell populations prior to and during treatment. In this review, we highlight the recent advances for single-cell analysis and discuss the challenges and prospects for molecular characterization of cancer cells, cancer stem cells and tumor-infiltrating immune cells. 关 键 词：生物标记物 肿瘤 治疗方法 临床分析
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