Efficacy of Xuebijing Injection(血必净注射液)on Cardiopulmonary Bypass-Associated Pulmonary Injury:A Prospective,Single-center,Double Blinded,Randomized Controlled Trial

查看全文 作　　者：GAO [1]Wei;LI [1]Na;CUI Xiao-[1]guang

机构地区：[1]Department of Anesthesiology, the Second Affiliated Hospital of Harbin Medical University

出　　处：《Chinese Journal of Integrative Medicine》索引2018年第24卷第11期,共7页

摘　　要：Objective: To evaluate the efficacy of Xuebijing Injection(血必净注射液, XBJ) on the lung injury induced by cardiopulmonary bypass(CPB). Methods: Fifty patients undergoing CPB were randomized to either the saline group or XBJ group according to a random number table(25 cases in each group). The patients in the saline group received saline and patients in XBJ group received XBJ at 12 h prior to the operation, at the beginning of the operation, and at 12 h after the second injection. The PaO_2/Fi O2 at extubation 3 days post-operation, duration of ventilation in the intensive care unit(ICU), and lengths of stay in the ICU and hospital were recorded. The levels of inflammatory mediators including interleukin(IL)-1β, IL-8, IL-10, and C-reactive protein(CRP) in bronchoalveolar lavage fluid(BALF) and plasma were measured. The neutrophil count and elastase neutrophil elastase in BALF were also measured. In addition, adverse events were monitored. Results: The PaO-2/FiO_2 in the XBJ group was higher than that in the saline group from 12 to 72 h post-operation(all P<0.05). The blood levels of IL-1β, IL-8, and CRP in the XBJ group from 12 to 72 h were all significantly lower than those in the saline group(all P<0.05). In contrast, the level of the anti-inflammatory cytokine IL-10 was significantly higher in the XBJ group than in the saline group(P<0.05). In addition, 4 patients presented with atelectasis in the saline group and none in the XBJ group. Ten patients experienced mild acute respiratory distress syndrome(ARDS) during hospitalization, and 5 patients with mild ARDS were in the XBJ group(P<0.05). Conclusion: XBJ shows protective potential against lung injury in patients who undergo CPB surgery, possibly through the downregulation of inflammatory mediators, reduction in neutrophil infiltration, and upregulation of IL-10(Trial registry: Chi CTR-TRC-14004628). 关键词：注射液随机化损害功效试用 IL-10 肺失明

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Efficacy of Xuebijing Injection(血必净注射液)on Cardiopulmonary Bypass-Associated Pulmonary Injury:A Prospective,Single-center,Double Blinded,Randomized Controlled Trial

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