Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

查看全文 作　　者：Estefania Caballano-[1]Infantes;José Terron-[1]Bautista;Amparo Beltrán-[1]Povea;Gladys M [1,2]Cahuana;Bernat [2,3,4]Soria;Hajji [5]Nabil;Francisco J [1,2,3]Bedoya;Juan R [1,2,3]Tejedo

机构地区：[1]Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide,41092 Seville,Spain;[2]Biomedical Research Network on Diabetes and Related Metabolic Diseases(CIBERDEM),Instituto de Salud CarlosⅢ,28029 Madrid,Spain;[3]Andalusian Center for Molecular Biology and Regenerative Medicine(CABIMER),41092 Seville,Spain;[4]Andalusian Center for Molecular Biology and Regenerative Medicine,Fundación Progreso y Salud,41092 Seville,Spain;[5]Centre for Pharmacology and Therapeutics,Division of Experimental Medicine,Imperial College London,Hammersmith Hospital Campus,London W12 0NN,United Kingdom

出　　处：《World Journal of Stem Cells》索引2017年第9卷第2期,共11页

基　　金：Supported by Ministerio de Ciencia E Innovación-Bernat Soria-Innpacto Proyect,No.IPT-2011-1615-900000;Instituto de Salud Carlos III,Gobierno de Espana-Bernat Soria,No.TERCEL RD06/0010/0025;Consejeria de Salud Junta de Andalucia-Francisco Javier Bedoya Bergua,No.PI-0105-2010;Consejeria de Economia Innovación Ciencia y Empleo-Junta de Andalucia-Francisco Javier Bedoya,No.CTS-7127/2011. 摘　　要：Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. 关键词：Endoplasmic reticulum stress Mitochondrial function Nitric oxide PLURIPOTENCY Cell differentiation Mitochondrial biogenesis

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Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

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