Phase Ⅱ study of docetaxel,cisplatin and capecitabine as preoperative chemotherapy in resectable gastric cancer

查看全文 作　　者：Anneriet E [1]Dassen;Nienke [2,3]Bernards;Valery EPP [3,4]Lemmens;Yes AJ van de [5]Wouw;Koop [1]Bosscha;Geert-Jan [2]Creemers;Hans JFM [6]Pruijt

机构地区：[1]Department of Gastro-intestinal Surgery and Surgical Oncology,Jeroen Bosch Hospital;[2]Department of Oncology,Catharina Hospital;[3]Comprehensive Cancer South (IKZ),Eindhoven Cancer Registry;[4]Department of Public Health,Erasmus MC University;[5]Department of Oncology,Vie Curi Hospital;[6]Department of Oncology,Jeroen Bosch Hospital

出　　处：《World Journal of Gastrointestinal Surgery》索引2016年第8卷第10期,共7页

摘　　要：AIM To investigate the feasibility of preoperative docetaxel,cisplatin and capecitabine(DCC) in patients with resectable gastric cancer.METHODS Patients with resectable gastric cancer fulfilling the inclusion criteria,were treated with 4 cycles of docetaxel(60 mg/m2),cisplatin(60 mg/m2) and capecitabine(1.875 mg/m2 orally on day 1-14,two daily doses) repeated every three weeks,followed by surgery.Primary end point was the feasibility and toxicity/safety profile of DCC,secondary endpoints were pathological complete resection rate and pathological complete response(p CR) rate.RESULTS All of the patients(51) were assessable for the feasibility and safety of the regimen.The entire preoperative regimen was completed by 68.6% of the patients.Grade Ⅲ/Ⅳ febrile neutropenia occurred in 10% of all courses.Three patients died due to treatment related toxicity(5.9%),one of them(also) because of refusing further treatment for toxicity.Of the 45 patients who were evaluable for secondary endpoints,four developed metastatic disease and 76.5% received a curative resection.In 3 patients a p CR was seen(5.9%),two patients underwent a R1 resection(3.9%).CONCLUSION Four courses of DCC as a preoperative regimen for patients with primarily resectable gastric cancer is highly demanding.The high occurrence of febrile neutropenia is of concern.To decrease the occurrence of febrile neutropenia the prophylactic use of granulocyte colonystimulating factor(G-CSF) should be explored.A curative resection rate of 76.5% is acceptable.The use of DCC without G-CSF support as preoperative regimen in resectable gastric cancer is debatable. 关键词：GASTRIC cancer PREOPERATIVE chemotherapy DOCETAXEL CAPECITABINE

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Phase Ⅱ study of docetaxel,cisplatin and capecitabine as preoperative chemotherapy in resectable gastric cancer

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